LPL 2026 Split 2 betting predictions – Wednesday, April 22

The fourth week of League of Legends Pro League 2026 Split 2 gets underway on Wednesday, April 22, with two intriguing Group Ascend matchups, as Team WE take on Weibo Gaming before Anyone’s Legend meet Ninjas in Pyjamas.

Here you can find our free League of Legends betting predictions and expert picks for the two games, along with odds from the top-rated esports bookmakers.

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  Fast Payouts

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TEAM WE vs WEIBO GAMING

Best Odds	WE +400 at BetOnline | WBG -714.29 at SportsBetting
When	April 22, 2026 | 17:00 CST
Watch Live	Lolesports, Twitch

Team WE are still searching for their first win of the split, and it is easy to see why the market is giving them very little chance here. Through the opening three weeks, WE have lost to Ninjas in Pyjamas, Top Esports, Bilibili Gaming, Invictus Gaming, and Anyone’s Legend, and they have rarely looked close to taking a map, let alone a full series.

Weibo Gaming have not exactly been convincing either, but they have at least shown more fight. Their lone win came against Invictus Gaming, and they also pushed JD Gaming in a competitive 1-2 loss last week. That is still a much stronger body of work than anything Team WE have managed so far.

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  The bookies' bookie

Like in previous seasons, Weibo remain a dangerous but frustrating side. They can be wildly inconsistent and are always capable of making life harder for themselves than it needs to be. Still, this is the kind of matchup where the gap in quality should be enough to carry them through.

It would be very on-brand for Weibo Gaming to make this messier than expected, but Team WE have shown nothing to suggest they can punish them. At the current price, the safer angle is backing Weibo to get the job done in straight maps.

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ANYONE’S LEGEND vs NINJAS IN PYJAMAS

Best Odds	AL -277.78 at BetOnline | NiP +200 at SportsBetting
When	April 22, 2026 | 19:00 CST
Watch Live	Lolesports, Twitch

Anyone’s Legend dropped their third match of the split on Sunday when they lost to Bilibili Gaming, falling to 2-3 overall. For a team that came into Split 2 with real expectations, that return is underwhelming, especially when their only wins have come against Weibo Gaming and Team WE.

A big part of the problem is stylistic. AL prefer to scale and play for cleaner mid-to-late game setups, but the current meta rewards teams that get on the front foot early. That puts them in a vulnerable spot against a Ninjas in Pyjamas side that has looked sharp in the opening stages of games.

NiP are still not a fully proven quantity, but they have already beaten Weibo Gaming, Team WE, and JD Gaming, which is a solid body of work. They look much more comfortable in the current pace of the league and have shown they can turn strong starts into series wins.

On paper, this is still Anyone’s Legend’s match to lose, but they have not shown enough to justify such a short price. With Ninjas in Pyjamas playing a style that naturally challenges AL’s biggest weakness, the upset looks very live here.