LoL Worlds 2025 Round 4 betting tips & predictions – October 22

League of Legends World Championship 2025 enters the fourth round of play on Wednesday, October 22, with the first two advancement matches.

Hanwha Life Esports will face off against the high-flying CTBC Flying Oyster, followed by an exciting matchup between G2 Esports and FlyQuest.

ESB brings you free League of Legends betting previews and expert picks for the two fixtures in China, with odds courtesy of the top-rated bookmakers in United States.

HANWHA LIFE ESPORTS vs CTBC FLYING OYSTER

Best Odds: HLE -333.33 at BetOnline | CFO +240 at SportsBetting
When: October 22, 2025 | 16:00 CST
Watch Live: Twitch, Lolesports

Hanwha Life Esports avoided dropping to the 1-2 bracket by beating 100 Thieves on Saturday in the fastest game of LoL Worlds 2025. While the clash seemed fairly close early, HLE blew open a huge lead after Herald and never looked back.

CTBC Flying Oyster enter this fixture off a tough 1-2 loss against Anyone’s Legend. It was a competitive, back-and-forth affair, with the Chinese squad squeezing out a reverse-sweep thanks to their excellent neutral objective setup.

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CFO deserve a lot of praise for what they’ve shown so far. The LoL Pacific Championship (LCP) representatives have held their own against some of the world’s best teams, both as a unit and individually, so it is fair to question why they are such massive underdogs with esports betting sites.

Hanwha Life Esports will have side choice, which bumps them up, but -333.33 is too short for a team who have faced only one top-class opponent — Anyone’s Legend — and lost badly.

CTBC Flying Oyster should be priced closer to even money, so they are an excellent pick to take at least one map. A smaller position on the underdogs winning is also worth considering.

G2 ESPORTS vs FLYQUEST

Best Odds: G2 -151.52 at BetOnline | FLY +110 at BetOnline
When: October 22, 2025 | 19:00 CST
Watch Live: Twitch, Lolesports

G2 Esports and FlyQuest can be very happy with the Round 4 draw, giving them both the easiest opponent out of the 2-1 teams. However, while this is a winnable match for both squads, the best LoL betting sites have G2 Esports priced as firm favorites to proceed to the knockout stage.

G2 Esports outplayed Bilibili Gaming in the last round, with a very good draft that tipped the scales heavily in their favor. They also easily punished BLG’s macro errors, especially around neutral objectives.

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FlyQuest had a much easier time last round when they beat Team Secret Whales. The Americas champions deserve praise for showing the ability to control the series wire-to-wire. Things did get a bit scary in early game, but Secret Whales were not allowed to gain much from it.

While G2 Esports have had a tougher schedule, that does not make them clear favorites in this contest. FlyQuest are arguably the most consistent Western team in the field and should offer some resistance to the 2019 LoL Worlds finalists.

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